August 14, 2000 05:15
Agilent Technologies' and Caliper Technologies' New Protein Analysis Kit To Speed Drug
Discovery Process
PALO ALTO, Calif. and MOUNTAIN VIEW, Calif., Aug. 14 /PRNewswire/ -- Agilent Technologies Inc. (NYSE: A) and Caliper Technologies Corp.
(Nasdaq: CALP) today announced the introduction of the Protein 200 LabChip(R) kit for the automated sizing and analysis of protein samples.
Used together with the Agilent 2100 bioanalyzer, the Protein 200 LabChip kit, featuring Caliper's LabChip technology, speeds and simplifies the
analysis of a wide variety of different protein samples including cell lysates, column fractions, and purified proteins. Applications range from
basic research to identification of potential drug targets to biopharmaceutical production.
The new protein kit significantly enhances throughput for protein sample analysis. Each LabChip kit enables the complete analysis of 10 protein
samples in less than a half hour, 5-10 times faster than traditional gel-based techniques. The LabChip format eliminates the laborious manual
staining and destaining steps required with traditional SDS polyacrylamide gel electrophoresis. With the vital integration of these processes, the
technology is a step closer to a complete laboratory-on-a-chip.
Compared with gels, the chip format also allows for real-time data acquisition and efficient sample comparison. This feature is especially
important for proteins, as sample quality can vary widely. Automated software extracts size and protein purity from the real-time digital data
which is displayed both visually in a simulated gel image and in exportable report formats.
"LabChip technology is a component of Millennium's strategy to build our leadership position in the industry as a technology innovator and
apply cutting-edge technologies to the future of drug development," said Craig Muir, vice president, process technology, Millennium
Pharmaceuticals, Inc., Cambridge, Massachusetts. "We are using Agilent 2100 bioanalyzers to assist in improving the efficiency and quality of
our drug discovery and development processes. This technology may play a role in streamlining our efforts to develop and commercialize
important new therapeutics and predictive medicine products."
The Agilent 2100 bioanalyzer is now offered with five LabChip kits including three for the high-resolution analysis of DNA samples, such as PCR
products and restriction digest fragments, one for the analysis of RNA samples typically used in gene expression applications, and the new
protein assay. Each kit is packaged complete and ready to use.
U.S. Pricing and Availability
The Protein 200 LabChip kit will be available in the United States, Japan and Europe and can be ordered directly through an Agilent sales office.
The price of the 25 chip kit is $500.
Information about Agilent's lab-on-a-chip products can be found on the Web at www.agilent.com/chem/labonachip. Information about Caliper's
LabChip technology and products can be found on the Web at www.calipertech.com.
About Caliper Technologies
Caliper Technologies Corp. is a leader in lab-on-a-chip technology. Caliper designs, manufactures, and commercializes LabChip devices and
systems that enable experiments that ordinarily require laboratories full of equipment and people to be conducted on a chip small enough to fit
in the palm of a child's hand. The chip contains a network of microscopic channels through which fluids and chemicals are moved in order to
perform the experiment. The LabChip system is designed to streamline and accelerate laboratory experimentation and has potential
applicability in a broad range of industries including pharmaceuticals, agriculture, chemicals and diagnostics. Caliper has established multiple
strategic and commercial alliances and has built a leading intellectual property estate in microfluidic technology.
Agilent Technologies in the Pharmaceutical Value Chain
Agilent Technologies is a recognized leading supplier of high-quality instrument and software solutions, such as liquid chromatographs and
mass spectrometers, to the pharmaceutical industry's drug development and quality control value chain. Today Agilent is furthering its reach
along the entire pharmaceutical value chain by providing tools to scientists working in the fields of disease and drug discovery. Within these
fields, Agilent is specifically targeting gene expression, genotyping and proteomics research with nanoscale technologies, such as micro-arrays
and microfluidic lab-on-a-chip tools, coupled with sophisticated informatics software. Pharmaceutical scientists can now use solutions that are
faster, less expensive, give higher-throughput and promote industry standards.
Information about Agilent Technologies' life sciences products and solutions can be found on the Web at
www.chem.agilent.com/scripts/phome.asp.
Agilent Technologies' and Caliper Technologies' New Protein Analysis Kit To Speed Drug
Discovery Process
PALO ALTO, Calif. and MOUNTAIN VIEW, Calif., Aug. 14 /PRNewswire/ -- Agilent Technologies Inc. (NYSE: A) and Caliper Technologies Corp.
(Nasdaq: CALP) today announced the introduction of the Protein 200 LabChip(R) kit for the automated sizing and analysis of protein samples.
Used together with the Agilent 2100 bioanalyzer, the Protein 200 LabChip kit, featuring Caliper's LabChip technology, speeds and simplifies the
analysis of a wide variety of different protein samples including cell lysates, column fractions, and purified proteins. Applications range from
basic research to identification of potential drug targets to biopharmaceutical production.
The new protein kit significantly enhances throughput for protein sample analysis. Each LabChip kit enables the complete analysis of 10 protein
samples in less than a half hour, 5-10 times faster than traditional gel-based techniques. The LabChip format eliminates the laborious manual
staining and destaining steps required with traditional SDS polyacrylamide gel electrophoresis. With the vital integration of these processes, the
technology is a step closer to a complete laboratory-on-a-chip.
Compared with gels, the chip format also allows for real-time data acquisition and efficient sample comparison. This feature is especially
important for proteins, as sample quality can vary widely. Automated software extracts size and protein purity from the real-time digital data
which is displayed both visually in a simulated gel image and in exportable report formats.
"LabChip technology is a component of Millennium's strategy to build our leadership position in the industry as a technology innovator and
apply cutting-edge technologies to the future of drug development," said Craig Muir, vice president, process technology, Millennium
Pharmaceuticals, Inc., Cambridge, Massachusetts. "We are using Agilent 2100 bioanalyzers to assist in improving the efficiency and quality of
our drug discovery and development processes. This technology may play a role in streamlining our efforts to develop and commercialize
important new therapeutics and predictive medicine products."
The Agilent 2100 bioanalyzer is now offered with five LabChip kits including three for the high-resolution analysis of DNA samples, such as PCR
products and restriction digest fragments, one for the analysis of RNA samples typically used in gene expression applications, and the new
protein assay. Each kit is packaged complete and ready to use.
U.S. Pricing and Availability
The Protein 200 LabChip kit will be available in the United States, Japan and Europe and can be ordered directly through an Agilent sales office.
The price of the 25 chip kit is $500.
Information about Agilent's lab-on-a-chip products can be found on the Web at www.agilent.com/chem/labonachip. Information about Caliper's
LabChip technology and products can be found on the Web at www.calipertech.com.
About Caliper Technologies
Caliper Technologies Corp. is a leader in lab-on-a-chip technology. Caliper designs, manufactures, and commercializes LabChip devices and
systems that enable experiments that ordinarily require laboratories full of equipment and people to be conducted on a chip small enough to fit
in the palm of a child's hand. The chip contains a network of microscopic channels through which fluids and chemicals are moved in order to
perform the experiment. The LabChip system is designed to streamline and accelerate laboratory experimentation and has potential
applicability in a broad range of industries including pharmaceuticals, agriculture, chemicals and diagnostics. Caliper has established multiple
strategic and commercial alliances and has built a leading intellectual property estate in microfluidic technology.
Agilent Technologies in the Pharmaceutical Value Chain
Agilent Technologies is a recognized leading supplier of high-quality instrument and software solutions, such as liquid chromatographs and
mass spectrometers, to the pharmaceutical industry's drug development and quality control value chain. Today Agilent is furthering its reach
along the entire pharmaceutical value chain by providing tools to scientists working in the fields of disease and drug discovery. Within these
fields, Agilent is specifically targeting gene expression, genotyping and proteomics research with nanoscale technologies, such as micro-arrays
and microfluidic lab-on-a-chip tools, coupled with sophisticated informatics software. Pharmaceutical scientists can now use solutions that are
faster, less expensive, give higher-throughput and promote industry standards.
Information about Agilent Technologies' life sciences products and solutions can be found on the Web at
www.chem.agilent.com/scripts/phome.asp.
