Bellicum Pharmaceuticals

Die vorbörslichen Gewinne sind kurz nach dem Handelsstart schon wieder verpufft.

https://www.globenewswire.com/news-release/2021/03/04/2187001/0/en/Bellicum-Announces-First-Reported-Use-of-CaspaCIDe-Safety-Switch-to-Mitigate-CAR-T-Cell-Toxicity.html "Bellicum Announces First Reported Use of CaspaCIDe® Safety Switch to Mitigate CAR-T Cell Toxicity March 04, 2021 07:30 ET | Source: Bellicum Pharmaceuticals, Inc. HOUSTON, March 04, 2021 (GLOBE NEWSWIRE) -- Bellicum Pharmaceuticals, Inc. (NASDAQ:BLCM), a leader in developing novel, controllable cellular immunotherapies for cancers, today announced the publication of a case report using the company’s CaspaCIDe (inducible caspase-9, or iC9) safety switch. The letter to the editor titled “Utility of Safety Switch to Abrogate CD 19 CAR T Cell-Associated Neurotoxicity” appeared as an ahead-of-print publication in the digital edition of Blood, a journal published by The American Society of Hematology. Link to article. The publication detailed a case report from an investigator-sponsored trial (IST) at the University of North Carolina Lineberger Comprehensive Cancer Center, where a Phase 1/2 trial is ongoing to test the safety and efficacy of autologous T lymphocytes genetically modified to express a CD19 chimeric antigen receptor (CAR) and iC9. A patient in the dose expansion cohort of this trial experienced a high grade neurologic adverse event with persistence of grade 3-4 immune effector cell-associated neurotoxicity syndrome (ICANS) for 72 hours despite standard care, and rimiducid was subsequently given per protocol to activate iC9. Within twelve hours of rimiducid administration, ICANS grade improved from 3 to 1 and was fully resolved after four days. This publication marked the first reported clinical use of the iC9 safety switch to mitigate a severe CAR-T-mediated adverse event refractory to standard of care treatment..." - Vorbörslich +15%

FDA hebt "klinischen Stop" von BPX-601 auf

https://seekingalpha.com/news/3655846-fda-lifts-clinical-hold-on-bellicums-bpx-601-cancer-trial

Ich habe so schnell nichts finden können dazu. Schönes Wochenende !!